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Best Picks for Guardians vs. Cubs

MLB: Chicago Cubs at Cleveland Guardians
© David Richard-Imagn Images
  • What: MLB Regular Season Game
  • When: July 1, 2025
  • Who:   Cleveland Guardians vs. Chicago Cubs
  • Time:  5:05 p.m. PST
  • Where: Wrigley Field (Chicago, IL)

The Cleveland Guardians (40-42) are set to face the Chicago Cubs (49-35) in the opening game of a three-game series at Wrigley Field on Tuesday at 5:05 p.m. PST.

This is the first meeting of the season; the Guardians swept the Cubs 3-0 last year. Cleveland is struggling, having lost four straight and failed to score in three games.

Their offense has posted a .595 OPS since June 5, averaging just 2.82 runs per game. On the road, they’ve averaged only 2.10 runs over their last ten games.

Meanwhile, the Cubs return home after a 3-4 road trip, feeling confident with a 25-15 record at Wrigley as they aim to snap a five-game skid against the Guardians.

Pitching Matchup

Gavin Williams (5-3, 3.68 ERA) will make his 17th start, featuring a 1.43 WHIP and 8.9 strikeouts per nine innings over 80 2/3 innings.

In his last outing, he pitched 5 1/3 innings, allowing 3 earned runs in a 5-4 win against the Toronto Blue Jays, and has yet to face the Cubs.

Matthew Boyd (7-3, 2.65 ERA), also making his 17th start, has a 1.10 WHIP with 8.1 strikeouts per nine innings through 91 2/3 innings.

He earned a win in his last game, throwing 6 scoreless innings in an 8-0 victory over the St. Louis Cardinals.

Against the Guardians, Boyd holds a career record of 4-7 with a 4.06 ERA in 17 games and boasts a 1.49 ERA over his last 6 starts.

Matthew Boyd is having a standout season with the fastest fastball of his career, managing to keep walk rates low and allowing no more than 2 runs in a start since May 23, reflected in his 1.49 ERA and 0.77 WHIP.

Cleveland, on the other hand, has struggled since June 3, posting a high-strikeout .605 OPS and a weak .547 OPS on the road.

They’ve also gone 1-9 in their last 10 series openers. I recommend betting on the Cubs to cover the run line at in this one.

Best Bet: Cubs -1.5 runs at +115 odds

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Tony Reyes is a sports betting analyst and reporter for Dice City Sports. You can follow him on X @TonyParlay.

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