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Best Picks for Chicago Cubs vs. Houston Astros

MLB: Chicago Cubs at Houston Astros
  • What: MLB Regular Season Game
  • When: June 29, 2025
  • Who:   Chicago Cubs vs. Houston Astros
  • Time:  11:10 a.m. PST
  • Where: Daikin Park (Houston, TX)

The Chicago Cubs (49-34) face the Houston Astros (49-34) Sunday in the final game of their three-game series, with the first pitch at Daikin Park set for 11:10 p.m. PST.

The season series is tied 1-1. The Cubs lost Friday’s opener 7-4 but rebounded with a 12-3 win on Saturday, led by Kyle Tucker’s four hits and three RBIs.

They’ve won three of their last four but are 4-6 in their previous ten games. Meanwhile, the Astros have won five of their last six games, even while scoring three or fewer runs in four of those.

Their pitching has been strong, allowing one or no runs in three of their last five games, putting them at the top of the AL West.

Pitching Matchup

In the upcoming game, Jameson Taillon (7-5, 4.47 ERA) will face Framber Valdez (8-4, 2.88 ERA). Taillon has a WHIP of 1.10 and has struck out 6.9 batters per nine innings over 90 2/3 innings.

In his last start, he allowed eight earned runs in 4 innings against the Cardinals. He is 4-3 this season with a 5.56 ERA on the road.

In his 17th start, Valdez has a WHIP of 1.13 with 8.9 strikeouts per nine innings. In his last outing, he threw seven scoreless innings against the Phillies. At home in 2025, he is 4-1 with a 2.04 ERA.

He holds a 0-0 record with a 9.00 ERA in one career start against the Cubs.

The Astros have won each of Valdez’s last nine starts, but six of those victories have come by just one run, making the attractive moneyline the better option.

Additionally, Houston is the second-best team at home, with a record of 31-14.

In contrast, the Cubs have dropped Taillon’s last two starts, giving up eight runs in each game. Their pitching has struggled significantly, allowing seven or more runs in seven of their last ten outings.

Best Bet: Astros Money Line at -135 odds

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Tony Reyes is a sports betting analyst and reporter for Dice City Sports. You can follow him on X @TonyParlay.

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