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Best Picks for Cubs vs. Astros

MLB: Chicago Cubs at Houston Astros
© Maria Lysaker-Imagn Images
  • What: MLB Regular Season Game
  • When: June 28, 2025
  • Who:   Chicago Cubs vs. Houston Astros
  • Time:  4:15 p.m. PST
  • Where: Daikin Park (Houston, TX)

The Chicago Cubs (48-34) will play the Houston Astros (49-33) on Saturday night in the second game of their three-game series.

The matchup at Daikin Park will begin at 4:15 p.m. PST. Currently, the Astros lead the season series 1-0.

The Cubs recently ended their two-game winning streak with a 7-4 defeat to Houston on Friday, where they entered as a +106 road underdog. Third baseman Matt Shaw contributed 3 RBIs despite the loss.

On the other hand, the Astros are on a five-game winning streak following their victory against Chicago on Friday as a -115 home favorite.

Right fielder Cam Smith and catcher Yainer Diaz hit three-run home runs, helping secure the win.

Pitching Matchup

Right-handed pitcher Colin Rea (4-3, 4.42 ERA) faces off against Lance McCullers Jr. (1-2, 4.91 ERA) in Saturday’s matchup. Rea is making his 13th start, coming off a loss in which he allowed seven earned runs over 5 1/3 innings against the Seattle Mariners.

He has a 1.39 WHIP and has struggled against the Astros in his career, with a 1-1 record and a 4.66 ERA over 9 2/3 innings.

McCullers Jr. will be making his eighth start. He is coming off a loss, in which he gave up four earned runs in 5 innings against the Chicago White Sox.

He has a 1.43 WHIP and significant home/road splits, with a 9.19 ERA at home compared to a 0.00 ERA on the road. This will be his first career appearance against the Cubs.

The Cubs have gone over the total in 7 of their last nine games, scoring at least four runs in 7 of those contests and six or more runs in 4 of the last 7. Additionally, they have allowed seven or more runs in 7 of their last nine games.

Meanwhile, the Astros have hit the over in 6 of their last 10 games. They scored at least four runs in 5 of those matchups and allowed four or more runs in 5 of their last nine games.

This one is going to be a high-scoring game.

Best Bet: Over 8.5 Runs at -110 odds

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Tony Reyes is a sports betting analyst and reporter for Dice City Sports. You can follow him on X @TonyParlay.

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